Sunday, April 28, 2013

Country superstar George Jones dead at 81

NASHVILLE, Tenn. (AP) ? When it comes to country music, George Jones was The Voice.

Other great singers have come and gone, but this fact remained inviolate until Jones passed away Friday at 81 in a Nashville hospital after a year of ill health.

"Today someone else has become the greatest living singer of traditional country music, but there will never be another George Jones," said Bobby Braddock, the Country Music Hall of Fame songwriter who provided Jones with 29 songs over the decades. "No one in country music has influenced so many other artists."

He did it with that voice. Rich and deep, strong enough to crack like a whip, but supple enough to bring tears. It was so powerful, it made Jones the first thoroughly modern country superstar, complete with the substance abuse problems and rich-and-famous celebrity lifestyle that included mansions, multiple divorces and ? to hear one fellow performer tell it ? fistfuls of cocaine.

He was a beloved and at times a notorious figure in Nashville and his problems were just as legendary as his songs. But when you dropped the needle on one of his records, all that stuff went away. And you were left with The Voice.

"He just knows how to pull every drop of emotion out of it of the songs if it's an emotional song or if it's a fun song he knows how to make that work," Alan Jackson said in a 2011 interview. "It's rare. He was a big fan of Hank Williams Sr. like me. He tried to sing like Hank in the early days. I've heard early cuts. And the difference is Hank was a singer and he was a great writer, but he didn't have that natural voice like George. Not many people do. That just sets him apart from everybody."

That voice helped Jones achieve No. 1 songs in four separate decades, 1950s to 1980s. And its qualities were admired by more than just his fellow country artists but by Frank Sinatra, Pete Townshend, Elvis Costello, James Taylor and countless others. "If we all could sound like we wanted to, we'd all sound like George Jones," Waylon Jennings once sang.

Word of his death spread Friday morning as his peers paid tribute.

Merle Haggard put it best, perhaps: "The world has lost the greatest country singer of all time. Amen."

"The greatest voice to ever grace country music will never die," Garth Brooks said. "Jones has a place in every heart that ever loved any kind of music."

And Dolly Parton added, "My heart is absolutely broken. George Jones was my all time favorite singer and one of my favorite people in the world."

In Jones' case, that's not hyperbole. In a career that lasted more than 50 years, "Possum" evolved from young honky-tonker to elder statesman as he recorded more than 150 albums and became the champion and symbol of traditional country music, a well-lined link to his hero, Williams.

Jones survived long battles with alcoholism and drug addiction, brawls, accidents and close encounters with death, including bypass surgery and a tour bus crash that he only avoided by deciding at the last moment to take a plane.

His failure to appear for concerts left him with the nickname "No Show Jones," and he later recorded a song by that name and often opened his shows by singing it. His wild life was revealed in song and in his handsome, troubled face, with its dark, deep-set eyes and dimpled chin.

In song, like life, he was rowdy and regretful, tender and tragic. His hits included the sentimental "Who's Gonna Fill Their Shoes," the foot-tapping "The Race is On," the foot-stomping "I Don't Need Your Rockin' Chair," the melancholy "She Thinks I Still Care," the rockin' "White Lightning," and the barfly lament "Still Doing Time." Jones also recorded several duets with Tammy Wynette, his wife for six years, including "Golden Ring," ''Near You," ''Southern California" and "We're Gonna Hold On." He also sang with such peers as Willie Nelson and Merle Haggard and with Costello and other rock performers.

But his signature song was "He Stopped Loving Her Today," a weeper among weepers about a man who carries his love for a woman to his grave. The 1980 ballad, which Jones was sure would never be a hit, often appears on surveys as the most popular country song of all time and won the Country Music Association's song of the year award an unprecedented two years in a row.

Jones won Grammy awards in 1981 for "He Stopped Loving Her Today" and in 1999 for "Choices." He was elected to the Country Music Hall of Fame in 1992 and in 2008 was among the artists honored in Washington at the Kennedy Center.

He was in the midst of a yearlong farewell tour when he passed away. He was scheduled to complete the tour in November with an all-star packed tribute in Nashville. Stars lined up to sign on to the show, many remembering kindnesses over the years. Kenny Chesney thinks Jones may have one of the greatest voices in not just country history, but music history. But he remembers Jones for more than the voice. He was picked for a tour with Jones and Wynette early in his career and cherishes the memory of being invited to fly home on Jones' private jet after one of the concerts.

"I remember sitting there on that jet, thinking, 'This can't be happening,' because he was George Jones, and I was some kid from nowhere," Chesney said in an email. "I'm sure he knew, but he was generous to kids chasing the dream, and I never forgot it."

Jones was born Sept. 12, 1931, in a log house near the east Texas town of Saratoga, the youngest of eight children. He sang in church and at age 11 began performing for tips on the streets of Beaumont, Texas. His first outing was such a success that listeners tossed him coins, placed a cup by his side and filled it with money. Jones estimated he made more than $24 for his two-hour performance, enough to feed his family for a week, but he used up the cash at a local arcade.

"That was my first time to earn money for singing and my first time to blow it afterward," he recalled in "I Lived to Tell it All," a painfully self-critical memoir published in 1996. "It started what almost became a lifetime trend."

The family lived in a government-subsidized housing project, and his father, a laborer, was an alcoholic who would rouse the children from bed in the middle of the night to sing for him. His father also noted that young George liked music and bought him a Gene Autry guitar, with a horse and lariat on the front that Jones practiced on obsessively.

He got his start on radio with husband and wife team Eddie & Pearl in the late 1940s. Hank Williams once dropped by the studio to promote a new record, and Jones was invited to back him on guitar. When it came time to play, he froze.

"Hank had 'Wedding Bells' out at the time," Jones recalled in a 2003 Associated Press interview. "He started singing it, and I never hit the first note the whole song. I just stared."

After the first of his four marriages failed, he enlisted in the Marine Corps in 1951 and served three years. He cut his first record when he got out, an original fittingly called "No Money in This Deal."

He had his first hit with "Why Baby Why" in 1955, and by the early '60s Jones was one of country music's top stars.

"I sing top songs that fit the hardworking, everyday loving person. That's what country music is about," Jones said in a 1991 AP interview. "My fans and real true country music fans know I'm not a phony. I just sing it the way it is and put feeling in it if I can and try to live the song."

Jones was married to Wynette, his third wife, from 1969 to 1975. (Wynette died in 1998.) Their relationship played out in Nashville like a country song, with hard drinking, fights and reconciliations. Jones' weary knowledge of domestic warfare was immortalized in such classics as "The Battle," set to the martial beat of "The Battle Hymn of the Republic."

After one argument, Jones drove off on a riding mower in search of a drink because Wynette had taken his car keys to keep him from carousing. Years earlier, married to his second wife, he had also sped off on a mower in search of a drink. Jones referred to his mowing days in the 1996 release, "Honky Tonk Song," and poked fun at himself in four music videos that featured him aboard a mower.

His drug and alcohol abuse grew worse in the late '70s, and Jones had to file for bankruptcy in 1978. A manager had started him on cocaine, hoping to counteract his boozy, lethargic performances, and Jones was eventually arrested in Jackson, Miss., in 1983 on cocaine possession charges. He agreed to perform a benefit concert and was sentenced to six months probation. In his memoir, "Satan is Real," Charlie Louvin recounts being offered a fistful of cocaine by Jones backstage at a concert.

"In the 1970s, I was drunk the majority of the time," Jones wrote in his memoir. "If you saw me sober, chances are you saw me asleep."

In 1980, a 3-minute song changed his life. His longtime producer, Billy Sherrill, recommended he record "He Stopped Loving Her Today," a ballad by Braddock and Curly Putnam. The song took more than a year to record, partly because Jones couldn't master the melody, which he confused with Kris Kristofferson's "Help Me Make it Through the Night," and partly because he was too drunk to recite a brief, spoken interlude ("She came to see him one last time/And we all wondered if she would/And it kept running through my mind/This time he's over her for good.")

"Pretty simple, eh?" Jones wrote in his memoir. "I couldn't get it. I had been able to sing while drunk all of my life. I'd fooled millions of people. But I could never speak without slurring when drunk. What we needed to complete that song was the narration, but Billy could never catch me sober enough to record four simple spoken lines."

Jones was convinced the song was too "morbid" to catch on. But "He Stopped Loving Her Today," featuring a string section that hummed, then soared, became an instant standard and virtually canonized him. His concert fee jumped from $2,500 a show to $25,000.

"There is a God," he recalled.

___

Italie contributed from New York.

Source: http://news.yahoo.com/country-superstar-george-jones-dead-81-164554929.html

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Saturday, April 27, 2013

Earth's Core Far Hotter Than Thought

Semantics, yes, but you can't grade "hotness" on either the Fahrenheit or Celsius scales by a percentage; otherwise 1 degree is infinitely "hotter" than 0 degrees!

To be fair, in Kelvin this is a 19% increase, so the semantic difference seems irrelevant. To put it in perspective, though, a 20% increase from room temperature (25 C or 298 K) would be 85 C (358 K); I'm pretty sure you'd agree that's "far" hotter!

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/WstB3EEEjKg/story01.htm

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NATO: 4 service members killed in plane crash

KABUL, Afghanistan (AP) ? A plane crashed in southern Afghanistan on Saturday, killing four international service members, NATO said.

Initial reporting indicated there was no enemy activity in the area at the time, but coalition personnel secured the site and the cause of the crash was being investigated, NATO said.

The brief statement did not identify the nationalities of the victims, or say where the plane went down.

However, Mohammad Jan Rasoulyar, deputy governor of the southern province of Zabul, said an aircraft belonging to foreign forces crashed Saturday afternoon in Shah Joy district. He said the site had been surrounded by international forces.

Source: http://news.yahoo.com/nato-4-members-killed-plane-crash-170208072.html

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Bird navigation: Great balls of iron

Apr. 25, 2013 ? Every year millions of birds make heroic journeys guided by Earth's magnetic field. How they detect magnetic fields has puzzled scientists for decades. Today, the Keays lab at the Research Institute of Molecular Pathology in Vienna has added some important pieces to this puzzle.

Their work, published in Current Biology, reports the discovery of iron balls in sensory neurons. These cells, called hair cells, are found in the ear and are responsible for detecting sound and gravity. Remarkably, each cell has just one iron ball, and it is in the same place in every cell. "It's very exciting. We find these iron balls in every bird, whether it's a pigeon or an ostrich" adds Mattias Lauwers who discovered them "but not in humans." It is an astonishing finding, despite decades of research these conspicuous balls of iron had not been discovered.

This finding builds on previous work by the lab of David Keays who last year showed that iron-rich cells in the beak of pigeons that were believed to be the magnetic sensors, were really just blood cells. "These cells are much better candidates, because they're definitely neurons. But we're a long way off to understanding how magnetic sensing works -- we still don't know what these mysterious iron balls are doing." said Dr Keays. "Who knows, perhaps they are the elusive magnetoreceptors" muses Dr Keays "only time will tell."

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The above story is reprinted from materials provided by Research Institute of Molecular Pathology.

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Journal Reference:

  1. Mattias Lauwers, Paul Pichler, Nathaniel?Bernard Edelman, Guenter?Paul Resch, Lyubov Ushakova, Marion?Claudia Salzer, Dominik Heyers, Martin Saunders, Jeremy Shaw, David?Anthony Keays. An Iron-Rich Organelle in the Cuticular Plate of Avian Hair Cells. Current Biology, 2013; DOI: 10.1016/j.cub.2013.04.025

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/IUgVDYZL2Mo/130426073811.htm

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Tuesday, April 16, 2013

Jessica Simpson's Baby Shower 2013

Jessica Simpson and her fianc?, Eric Johnson, celebrated their baby shower with family and celebrity pals yesterday at the Hotel Bel-Air in LA. Along with Jessica's mom, Tina, sister Ashlee, and daughter Maxwell, other pals including Ken Paves, Jessica Alba and her husband, Cash Warren, and Chelsea Handler and her boyfriend, Andr? Balazs, turned out with gifts. The decor at Jessica Simpson's baby shower was appropriately boy-themed, since she and Eric are expecting a son. The event, planned by Mindy Weiss, had a Tom Sawyer motif, and guests were treated to comfort food like sliders and pigs in a blanket.

Source: http://www.popsugar.com/Jessica-Simpsons-Baby-Shower-2013-29435413

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Monday, April 15, 2013

Posture Predicts Disability Risk, Study Shows | Health and Fitness

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Source: http://hefner-adulterant.blogspot.com/2013/04/posture-predicts-disability-risk-study.html

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China WHO chief: Beijing H7N9 case not surprising

BEIJING (AP) ? A World Health Organization official said Sunday that it wasn't surprising that a new strain of bird flu has spread to China's capital after sickening dozens in the eastern part of the country.

Up until Saturday when Beijing officials reported the capital's first case of H7N9, all cases had been in Shanghai and other eastern China areas. On Sunday, the first two cases were reported in central Henan province, which is next to Beijing.

It's not the case that everyone confirmed infected with H7N9 was "clustered in one small area with the same source of exposure," said Michael O'Leary, head of WHO's office in China. "So we've been expecting new cases to occur ... Furthermore, we still expect that there will be other cases."

A 7-year-old girl was Beijing's first confirmed case of H7N9, which has now sickened 51 people, of whom 11 died.

Health officials believe the virus that was first spotted in humans last month is spreading through direct contact with infected fowl.

O'Leary said "the good news" was that there was still no evidence that humans had passed on the virus to other humans.

"As far as we know, all the cases are individually infected in a sporadic and not connected way," he said, adding that the source of infection is still being investigated.

The girl, whose parents are in the live poultry trade, was admitted to a hospital Thursday with symptoms of fever, sore throat, coughing and headache, the Beijing Health Bureau said.

O'Leary said early treatment can be effective, as demonstrated by the girl who was recovering in hospital and in stable condition.

In the only other reported cases outside of eastern China, health officials in Henan province announced that tests on two men Thursday revealed they had the virus.

They said a 34-year-old restaurant chef who had displayed flu symptoms for about a week was in critical condition in hospital, while a 65-year-old farmer who was in frequent contact with poultry was in stable condition after receiving treatment.

They said 19 people who had been in close contact with the two men had not shown any flu symptoms.

China has been more open in its response to the new virus than it was a decade ago with an outbreak of SARS, when authorities were highly criticized for not releasing information.

Source: http://news.yahoo.com/china-chief-beijing-h7n9-case-not-surprising-040034007.html

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U.S. data douses equity rally, gold down 4 percent

By Herbert Lash

NEW YORK (Reuters) - Commodities sold off on Friday, with gold sinking more than 4 percent to break below $1,500 an ounce, while world equity markets fell after a dour reading of U.S. consumer sentiment and poor retail sales reinforced fears of a weak U.S. economy that would hurt global growth.

Gold fell to its lowest levels since July 2011, hurt by a draft plan for Cyprus to sell gold reserves as part of its bailout by international lenders.

Gold is now some 22 percent below the record peak of $1,920.30 an ounce set in September 2011.

Despite the sell-off in commodities, U.S. stocks trimmed some losses by the session's end to close out the second-best week of gains so far this year.

"The scale of the decline has been absolutely breathtaking," Societe Generale analyst Robin Bhar said. "We tried to rally and that just didn't get anywhere ... There hasn't been any downside support, it's like a knife through butter."

Silver led a sell-off in precious metals, falling 5.1 percent. Other commodities also fell, with Brent oil hitting an eight-month low just above $101 a barrel as the outlook for global crude demand growth dimmed. Brent later pared losses to settle above $103 a barrel.

Investors said the breadth of the sell-off appeared tied to volatility in the price of Japanese government bonds, which has forced certain holders to sell other assets to meet the risk modeling of their investment portfolios.

Both the Cypriot plan to sell gold and volatility in the Japanese bond market are most likely behind the gold plunge, said Jeffrey Sherman, a commodities portfolio manager at DoubleLine Capital LP in Los Angeles.

"The economic sensitive commodities - energy, industrial metals - have been signaling weakness for the past two months and you could see that many investors are now reassessing global growth prospects," Sherman said.

Wall Street fell after the Commerce Department reported U.S. retail sales fell by 0.4 percent in March, the second contraction in three months. Analysts expected that sales would be flat and the decline spurred worries about consumer spending - the linchpin of the U.S. economy.

Also weighing on stocks was a Thomson Reuters/University of Michigan survey that showed consumer sentiment tumbled to a nine-month low in April, with Americans especially gloomy about the long-term health of the U.S. economy.

The drop in oil prices pressured material and energy shares. Quarterly results from JP Morgan Chase & Co and Wells Fargo & Co that failed to impress added to the negative sentiment.

"We're due for choppiness given the run we've had, especially since the strong data we've seen recently looks increasingly misleading," said Hank Herrmann, chief executive of Waddell & Reed Financial Inc in Overland Park, Kansas.

"We're moving at a slower pace and those who got overly excited about GDP growth are probably pulling in their horns a bit."

The Dow Jones industrial average <.dji> closed down 0.08 points at 14,865.06. The Standard & Poor's 500 Index <.spx> fell 4.52 points, or 0.28 percent, at 1,588.85. The Nasdaq Composite Index <.ixic> slid 5.21 points, or 0.16 percent, at 3,294.95.

For the week, the Dow rose 2.1 percent, S&P gained 2.3 percent and Nasdaq jumped 2.8 percent.

MSCI's all-country world equity index <.miwd00000pus> fell 0.48 percent, while the pan-European FTSEurofirst 300 <.fteu3> of leading regional shares closed down 0.9 percent at 1,182.10.

European shares snapped four straight days of gains amid concerns about the Cypriot economy and on the euro zone's debt crisis.

German Bunds rose and are expected to advance in coming sessions on concerns Cyprus might need more bailout funds, lifting demand for low-risk debt.

The Bund future was 63 ticks up on the day at 145.88.

Prices for U.S. Treasuries rose, with the 30-year bond gaining more than a point and the yield on the benchmark 10-year note falling to 1.72 percent.

The benchmark 10-year U.S. Treasury note rose 20/32 in price to yield 1.7225 percent, while the 30-year U.S. Treasury bond was up 1-19/32 in price to yield 2.9207 percent.

"A combination of soft activity and extremely benign inflation data is a good signal for U.S. Treasuries, which are poised to rally on these and similar data over the coming months," said Rob Carnell, chief international economist at ING Bank.

A report from the U.S. Labor Department showed wholesale prices fell sharply in March due to lower gasoline costs. The seasonally adjusted producer price index fell 0.6 percent, the largest drop since May, after rising 0.7 percent in February.

Spot gold prices fell $71.98 to $1,488.70 an ounce.

The dollar fell 0.9 percent to 98.77 yen.

Brent crude fell $1.16 to settle at $103.11 a barrel, while U.S. crude oil futures settled down $2.22 to $91.29.

(Additional reporting by Jennifer Ablan; Editing by Leslie Adler, Chizu Nomiyama and Andre Grenon)

Source: http://news.yahoo.com/u-data-douses-equity-rally-gold-down-4-205050144--finance.html

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Freezing nerves knocks pain out cold

Apr. 14, 2013 ? Using a tiny ball of ice, a minimally invasive interventional radiology treatment called cryoneurolysis safely short circuits chronic pain caused by nerve damage, according to data being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

"Cryoneurolysis could have big implications for the millions of people who suffer from neuralgia, which can be unbearable and is very difficult to treat," said William Moore, M.D., medical director of radiology at Stony Brook University School of Medicine in Stony Brook, N.Y. "Cryoneurolysis offers these patients an innovative treatment option that provides significant lasting pain relief and allows them to take a lower dose of pain medication -- or even skip drugs altogether," added Moore, an interventional thoracic radiologist at Stony Brook.

More than 15 million Americans and Europeans suffer from neuralgia, in which nerves are damaged by diabetes, surgery or traumatic injury, Moore noted. Sufferers often rely on pain medications, which have side effects and may not provide enough relief. Cryoneurolysis uses a small probe that is cooled to minus 10 to minus 16 degrees Celsius, creating a freezer burn along the outer layer of the nerve. This interrupts the pain signal to the brain and blunts or eliminates the pain while allowing the damaged nerves to grow over time, explained Moore.

In the study, 20 patients received cryoneurolysis treatment for a variety of neuralgia syndromes and were evaluated using a visual pain scale questionnaire immediately after treatment during one-week, one-month and three-month follow-ups after the initial procedure. Prior to treatment, patients' pain plummeted from an average of 8 out of 10 on the pain scale to 2.4 one week after treatment. Pain relief was sustained for about two months after the procedure. Pain increased to an average of 4 out of 10 on the scale after six months due to nerve regeneration, Moore said. He recommends repeat cryoneurolysis treatments as needed per patient, however, some patients will receive up to a year of pain relief from a single treatment, he said.

In the treatment, an interventional radiologist makes a nick in the skin near the source of pain and inserts a small probe about the size of an IV needle that is used to draw blood. Under imaging guidance, the probe is advanced through the skin to the affected nerves. Cooled with pressurized gas, the probe creates ice crystals along the edge of the nerves. "The effect is equivalent to removing the insulation from a wire, decreasing the rate of conductivity of the nerve. Fewer pain signals means less pain, and the nerve remains intact," he explained. Additional comparative studies are needed, said Moore.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/mFU8mhuQZ8I/130414121144.htm

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Technology Has Sure Moved On in the Last 20 Years

Sometimes, it's easy to forget just how much technology has changed over the last few decades. Fortunately, Redditor ImTheGuyWhoLoveGems decided to remind us all—and, boy, should we be happy about the progress. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Qkrr8ScpH1c/technology-has-sure-moved-on-in-the-last-20-years

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Source: http://www.covol.org/professional-search-engine-optimisation-businesses-keep-command-the-web.html

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Sunday, April 14, 2013

Report: To Settle With EU Regulators, Google Proposes To Link To 3 Competitors Every Time It Links To Itself

google-euGoogle’s search results in Europe could soon look a bit different if a number of new reports about the company’s settlement with the European Union’s competition commission are correct. After a three-year investigation into its potentially anti-competitive practices, Google submitted its proposal for an agreement with the EU last week, but the details remained under wraps. According to reports from the Financial Times and The Wall Street Journal, however, Google’s proposal includes a number of changes to how it will do business (at least in the EU). According to these reports, Google has offered to “make users clearly aware” when it is linking to its own specialized services and vertical search engines. Every time Google promotes one of its own links, it will also show “at least three links to rival, non-Google sites that have information relevant to a user’s query,” the Wall Street Journal’s Amir Efrati reports. So whenever a search on Google would naturally highlight a result from Google+ Local, Google would also add links to sites like Yelp, UrbanSpoon, TripAdvisor or other relevant sites. This part of the agreement would at least cover Google’s search services for restaurants, finance and shopping. Results from Google News, the Financial Times says, would “merely need to be labelled and separated.” Under this proposed settlement, Google will also offer sites the ability to easily remove 10 percent of their content from its vertical search engines (though it’s not clear how this would actually work) and make it easier for advertisers to move their campaigns to other search engines (similar to what Google is doing in the U.S. after its settlement with the Federal Trade Commission earlier this year).?Google’s search algorithm itself would remain untouched in this agreement. If the EU agrees to these terms, Google will avoid the large financial penalties that the EU could have levied against the search company. The proposal, if the reports are correct, would be binding for five years, and a neutral third party would ensure that Google doesn’t stray from the agreement. Google competitors, whose official complaint started this investigation, were probably hoping for larger changes, and fines will probably not be in favor of these relatively small changes Google is offering to make. Last week, FairSearch.org already filed another complaint against Google in the EU. This time, the organization, which is backed by Microsoft, Expedia, Oracle, TripAdvisor and 13 other search and technology companies,

Source: http://feedproxy.google.com/~r/Techcrunch/~3/S840A4ioQyE/

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Jon Stewart on Rand Paul's Embarrassing Howard University Fail (Little green footballs)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/298606817?client_source=feed&format=rss

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Alloa V Forfar At Recreation Park : Match Preview - Sport.co.uk

Alloa V Forfar - view commentary, squad, and statistics of the game live.

Alloa aim to consolidate second spot

Boss Paul Hartley has a fully-fit squad to choose from as Alloa look to move ever closer to securing second place in the Second Division by seeing off visitors Forfar.

Alloa, who cannot now catch champions Queen of the South, hold a 10-point advantage over fourth-placed Forfar in the standings.

Hartley said: "We visited Ayr last weekend and put in a very good disciplined performance to come back with a 2-0 win. I reckon we are hitting form at the right time to have a good end to the season.

"I watched Forfar in midweek and they won well at Brechin so I know we will have to put in another good performance to win.

"Forfar looked like a side who are more than happy to attack teams to get the wins they need to get into the play-offs so this should be a cracking game."

Forfar head to Alloa looking for a fourth successive victory but they are likely to be without Stephen Tulloch and Martyn Fotheringham.

Tulloch is struggling with a pelvic injury while Fotheringham is a major doubt with an ankle problem, with Mick Dunlop (knee) still on the sidelines.

Odmar Faero should make his comeback after shaking off a head injury, with Ross Campbell and Jordan Brown also set to return to the starting line-up after injury.

Loons boss Dick Campbell said: "We are playing well just now and hopefully that will lead to a win against Alloa. Our first-half display against Brechin in midweek was tremendous and one of the best I have seen from Forfar.

"Alloa have beaten us three times this season by one goal so we are very keen to get the three points this time."

Source: http://www.sport.co.uk/football/alloa-v-forfar-at-recreation-park-match-preview/3993194/

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Beijing reports its first case of the new bird flu virus

BEIJING (AP) ? A 7-year-old girl has become Beijing's first confirmed case of a new strain of the bird flu virus that has killed 11 people and sickened 37 others in eastern China, officials said Saturday.

The girl, whose parents are in the live poultry trade, was admitted to a hospital Thursday with symptoms of fever, sore throat, coughing and headache, the Beijing Health Bureau said. She was confirmed to be infected with the H7N9 virus on Saturday after tests by disease control and prevention centers, the bureau said.

The case in China's capital is the first one reported outside eastern China, where the virus was first spotted in late March, prompting massive slaughtering of live fowl and bans on the poultry trade in several cities, including the financial hub of Shanghai. Shanghai, the center of the outbreak, has reported 21 cases, including seven fatalities. One person was discharged after recovering, the local government has said.

The Beijing Health Bureau said the girl was recovering in a hospital and was in stable condition.

Shanghai authorities said Saturday that a 56-year-old man, the husband of a woman hospitalized with the virus earlier this month, became the city's latest case after testing positive for H7N9, but that it was inconclusive as to whether he had been infected by his wife.

Health officials believe people are contracting the H7N9 virus through direct contact with infected fowl and say there is no evidence the virus is spreading easily among people.

Neighboring Jiangsu province on Saturday confirmed two more cases ? a 77-year-old woman and a 72-year-old man, both in critical condition. The province has reported 14 cases, including one fatality.

Zhejiang province has reported 11 cases, including two reported Saturday by state media, and Anhui province has had two.

China has been more open in its response to the new virus than it was a decade ago with an outbreak of SARS, when authorities were highly criticized for not releasing information.

Source: http://news.yahoo.com/beijing-reports-1st-case-bird-flu-virus-110736344.html

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Tuesday, April 9, 2013

Novel drug combination showed antitumor activity in patients with incurable BRCA-deficient cancers

Apr. 7, 2013 ? When given sequentially, two orally available experimental drugs -- sapacitabine and seliciclib -- worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. There are no drugs yet approved specifically for this patient population.

"Since we began to enroll predominantly patients who carried a BRCA mutation in the study, we have seen several responses among those patients, as well as instances of prolonged stable disease lasting more than a year," said Geoffrey Shapiro, M.D., Ph.D., associate professor of medicine at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Mass.

Shapiro and colleagues initially designed the phase I study to exploit preclinical results that suggested that sapacitabine and seliciclib worked together synergistically. Sapacitabine is an oral nucleoside analogue that induces single-strand damage to DNA. If the damaged DNA is not repaired, it ultimately results in cell death. Repair of sapacitabine-induced DNA damage requires BRCA proteins, suggesting that BRCA-deficient cancers may be particularly sensitive.

Seliciclib inhibits cyclin-dependent kinases (CDKs); CDK inhibition has been shown to augment cancer cell death induced by drugs like sapacitabine by multiple mechanisms, in part by suppressing DNA repair pathways.

Researchers enrolled 38 patients with incurable solid tumors and adequate organ function. They assigned patients to treatment with sapacitabine twice daily for seven days followed by seliciclib twice daily for three days.

Four patients with BRCA-deficient pancreatic, breast or ovarian cancers had confirmed ongoing partial responses to the drug combination. Three patients are experiencing partial responses, with the longest lasting more than 78 weeks.

Furthermore, researchers observed stable disease of 12 weeks or more in eight additional patients, including two patients with ovarian and breast cancers who carried the BRCA mutation and whose stable disease lasted 64 weeks and 21 weeks, respectively.

The maximum tolerated doses were 50 mg sapacitabine twice daily and 1,200 mg seliciclib twice daily. Dose-limiting toxicities included reversible transaminase elevations and neutropenia. Adverse events were mild to moderate in intensity.

Results of skin biopsies after treatment showed a 2.3-fold increase in DNA damage induced by sapacitabine, as measured by gamma-H2AX immunohistochemistry. Additional DNA damage occurred after treatment with seliciclib with a 0.58-fold further increase in gamma-H2AX staining.

"Initially in the dose-escalation phase of the trial, this combination produced stable disease of modest duration in some patients, which has been the experience with sapacitabine and CDK inhibitors in solid tumors," Shapiro said. "However, other published research during the course of the study indicated the role of the homologous recombination pathway, dependent on BRCA proteins, for repair of sapacitabine-induced DNA damage. Additionally, the CDK proteins were implicated in DNA repair pathways. These findings prompted us to enroll patients with advanced cancer who had the BRCA mutation and led to the first partial responses and instances of durable stable disease."

Based on these emerging results, Shapiro and colleagues continue to enroll appropriate patients in the trial, where the combination has been most efficacious. Additional schedules of the combination therapy are under evaluation. According to Shapiro, if further work continues to confirm BRCA mutation status as a potential biomarker for response, these drugs, both individually and in combination, should ultimately be evaluated in larger groups of patients who carry BRCA mutation. If successful, these drugs may provide an important treatment alternative for patients with BRCA-deficient cancers.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/E70r6AgCkpg/130407183555.htm

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Roger Ebert's funeral draws fans and the famous

By Gael Fashingbauer Cooper, TODAY

Famous names, including Chicago mayor Rahm Emanuel and Illinois governor Pat Quinn were among those who eulogized film critic Roger Ebert at his funeral Monday at Chicago's Holy Name Cathedral. The Pulitzer Prize-winning movie critic died Thursday at age 70 after a lengthy battle with cancer.

John Gress / Reuters

Chaz Ebert watches as her husband Roger Ebert's casket is carried in to his funeral in Chicago.

Emanuel called Ebert, "the most American of American critics in the most American of cities." Emanuel said he always had two questions about any movie he wanted to see, "what time does it start and what did Roger think about it."

"The final reel of Roger's life may have run to the end, but his memory will never fade," said Emanuel.

Quinn recalled meeting the critic at his film festival, Ebertfest, and recalled how he always stood for social justice.

"We love you, Roger," Quinn said. "We always will. Thumbs up!"

Jonathan Jackson, son of the Rev. Jesse Jackson, delivered thoughts from his father and also relayed comments from filmmaker Spike Lee. Jackson and Lee both praised Ebert for his attention to African-American film.?

Former Sun-Times publisher John Barron recalled Ebert's devotion to the newspaper industry, saying that being his boss was "the easiest job I ever had." Barron noted that "we at the Sun-Times were always proud to say we worked where Roger Ebert worked."

Ebert's stepdaughter Sonia recalled his love for her family, especially her children, saying "he embraced all of us as his own." Ebert married her mother, Chaz Hammelsmith, in 1992 at age 50. "Roger, I want to thank you for nothing more than being you and loving us," she said.

Ebert's widow also spoke, though she said that when she woke up she wasn't sure she'd be able to do so. "This morning I didn't want to get out of bed," she said. "And then it felt like he was there with me." Indicating her elaborate black veiled hat, she said "he loves this hat, that's why I wore it today."

John Gress / Reuters

Roger Ebert's widow, Chaz, spoke briefly at his funeral service and noted that the black veiled hat she wore was a favorite of her husband's.

Ebert's granddaughter, Raven Evans, read from the Book of Isaiah, and filmmaker Gregory Nava delivered the petitions. "A heart as great as Roger's can never die," Nava said.

The funeral homily made mention of Ebert's recent blog post, "How I Am A Roman Catholic," written as Pope Benedict gave way to Pope Francis. Movies "Vanilla Sky" and "The Hours" were also mentioned, as was "Silence," Shusaku Endo's 1966 novel about a Jesuit missionary in 17th century Japan.

"We believe for (Ebert) life has changed, not ended," said Rev. John Costello.

The public was welcome at the service, and the Sun-Times reported that young film critic Matt Fagerholm, who writes for HollywoodChicago.com, was first in line.

Fagerholm was a college student when he met Ebert. "Just being able to have him as a colleague and a friendly acquaintance was a huge honor," he told the newspaper.

Former CBS anchor Bill Kurtis and "Hoop Dreams" director Steve James, who is making a documentary on Ebert?s life, also attended, according to the Sun-Times. Columnist Richard Roeper, who co-hosted "At the Movies with Roger Ebert" after Gene Siskel's death, was among the pallbearers.

Ebert's website requested donations to the Ebert Foundation, a non-profit that supports arts and education programs, in lieu of flowers.?

Another memorial to Ebert will be held Thursday night at the Chicago Theatre, where the critic often attended movie screenings and where a sidewalk star honors him. That event will include clips from Ebert's television show and musical performances.

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Source: http://todayentertainment.today.com/_news/2013/04/08/17655384-at-roger-eberts-funeral-fans-and-the-famous-mingle?lite

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A Drink a Day Raises Cancer Risk, Study Says | BU Today | Boston ...

A glass and a half a day or less of alcohol may raise your cancer risk, a BU researcher says. Photo by flickr contributor jyryk

How many of us enjoy a glass or two of wine at dinner? How many of us have read that moderate drinking of red wine is good for the heart?

How many of us know that even moderate drinking might increase our cancer risk?

That eye-catching news turned a few media heads after a recent study was published in the American Journal of Public Health. The authors, including Timothy Naimi, a School of Medicine and School of Public Health associate professor, attribute 6,000 American deaths annually to cancer from moderate drinking, which they define as a drink and a half per day or less. Add in alcohol consumption at all levels and the total surges to 20,000 cancer deaths a year, according to the study. (For perspective, that 20,000 figure represents 3.5 percent of all cancer deaths in the country.)

For men, lethal alcohol-caused cancer typically afflicts the mouth, throat, and esophagus, the researchers say. In women, breast cancer is the most common cancer killer linked to alcohol consumption.

The researchers synthesized risk estimates from hundreds of other studies to come up with their findings. Naimi believes the big takeaway is the total number of deaths, the role of excessive drinking, and the fact that these deaths are preventable. But as everyone knows that drinking to excess is bad for a host of reasons, he understands the headlines generated by the findings on moderate drinking.

Evidence of excessive drinking?s role in cancer is much greater than that for the role of modest drinking, says Naimi, an alcohol epidemiologist specializing in binge and youth drinking and alcohol policy. The idea that limited drinking causes cancer ?should be interpreted with caution.?I have nothing against alcohol. My background is as a physician, and my interest is in seeing harm from alcohol minimized.?

But some doctors say the moderate drinking findings need to be taken seriously, and Naimi says there is evidence from the literature he and his team reviewed supporting their concerns. And, he adds, deaths from alcohol ?dwarf any small number of people who may derive benefit from low-dose alcohol.? Indeed, among all people who start drinking, 5 to 10 times as many die from it as are benefited by it, according to Naimi, who notes that you can?t predict when people begin drinking whether they?ll wind up an alcoholic: ?You don?t know prospectively who?s going to end up as a moderate drinker.?

Nor is he convinced by studies showing heart benefits from moderate drinking. For one thing, he says, those studies have never included the accepted standard in scientific research: a randomized, controlled study comparing moderate drinkers with teetotalers. Also, moderate drinkers tend to come from higher on the socioeconomic ladder, a rung at which people tend to be healthier. In other words, moderate drinking may be ?a reflection of people?s social position and good health. It?s not its genesis,? Naimi says.

Studies linking alcohol to cancer are based on calculations using three types of data, he says: the numbers of people who drink at different levels, the prevalence of various cancers at those various drinking levels, and the number of cancer deaths among people at each level. The American Cancer Society lays out the cancers for which the evidence of an alcohol link is strongest, while adding that the precise mechanism for how drinking leads to the disease is not certain.

As for the argument that there?s a certain risk with much of the food we consume?nonorganic fruits and vegetables marinated in pesticides, for example, or brown rice, once thought to be healthy, but now found to contain risky levels of arsenic?Naimi replies, ?Alcohol is not a food. Alcohol is a drug,? and one with so-called empty calories that lack nutritional value.

?I wouldn?t put alcohol on a par with fruits and vegetables,? he says?especially as fruits and vegetables won?t kill you the way drunk driving can.

Source: http://www.bu.edu/today/2013/a-drink-a-day-raises-cancer-risk-study-says/

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Monday, April 8, 2013

4 Benefits to Hiring a Private Travel Guide | Travel Insurance Review

Hiring a private travel guideBefore you start envisioning your standard tour guide standing in the front of a crowded bus full of tourists ? much like a moving fish tank for the locals to gawk at ? barking out boring facts about things you couldn?t care less about, there are many different types of travel guides.

Many travel guides these days are independent, self-promoting individuals who are experts in a particular area. They usually take very small, intimate groups to see those sights and restaurants that only the locals know. Even travelers who prefer checking out things on their own may find that hiring a private tour guide, especially when you have a short amount of time and don?t know your way around, is the best way to really enjoy your time in a particular place.

There?s no right or wrong way to travel to and in a new region of the world, but how you go about it depends on a few factors:

  • Your budget
  • The amount of time you have
  • What you want to see and do

The kind of travel guide we?re speaking of here is not one of the fast-talking touts who pester anyone with a suitcase at the local point of entry. Instead, we?re talking about a real live local who knows the area you are visiting and can take you to the places you never knew existed ? even introduce you to the locals.

1. Immediate access to things you wouldn?t be able to see otherwise

Something you may not know from the travel books is that many museums and monuments round the world work with independent local travel guides whom they can trust to bring in visitors and not require the services of the on-site staff too much and as a result, they?re more willing to allow privileges to those traveling with a known travel guide.

When traveling with a travel guide, you?re often privy to access to things you wouldn?t be able to see otherwise. For example, if you?re traveling in Rome and want to see the Vatican, you?ll wait for hours in a line but with a guide, you?ll get in a lot quicker. A local tour guide will also best understand the quickest ways to get around the new area just like you know how best to get around in your home town.

2. The ability to learn about the culture from someone on the inside

One of the first and most important benefits of hiring a local travel guide is the chance it gives you to learn about the culture from someone on the inside.

A good local travel guide will be able to explain the local culture ? that is, why people are doing what they do every day ? from the insider perspective. They should also make sure you, as a foreigner in a new place, don?t feel out of place.

3. The flexibility to tailor your travel to what you want to see

While most travelers think of standard tour buses packages when they think of the term tour guide, there are many private travel guides who will tailor the experience to include the sights and attractions you want to see instead of taking the standard tourist route.

Hiring a private tour guide gives a traveler an individual experience with a personalized touch and avoids the crowds. Plus, in most cases, the tour price includes discounted admission into the attractions as well as all of the subway, bus, taxi and even boat fares ? a fact that can help offset the cost of hiring a private travel guide to the budget traveler.

4. Insight, companionship, and a little more security

In some places of the world, the bureaucracy and red tape makes it difficult for a foreigner to get anywhere; in other places, it?s simply not safe to travel alone. For many travelers ? and especially solo travelers ? the value of having a local expert show them around and negotiate with the locals is priceless.

Of course, the added security of 1. knowing where you?re going (or at least looking like it with a guide striding by your side), and 2. having another person along with you when you explore means a little extra security. No one plans to get robbed or kidnapped, but it?s much less likely with a local at your side.

When should you hire a private travel guide?

There are some trips when it really helps to hire a private travel guide. These include:

  1. When you have very little time. Business travelers have learned the value of a private tour guide when they have just a little time in a place and still want to have a meaningful experience.
  2. When you are visiting a relatively dangerous or chaotic location. Anyplace with a reputation for being dangerous or unpredictable means a private travel guide can help keep you safe and out of tough spots.
  3. When you are visiting a particularly popular location. A private tour guide will know the tricks and tactics to help yoy get the most out of a heavily visited location by going before or after the crowds, for example.
  4. When you?re on a long stay and want to really know the area. Hiring a private travel guide at the start of a longer stay can help you get your bearings for the area and will often leave you with a list of things to explore on your own.
  5. When you?re taking an adventure trip. Unless you?re an expert at your chosen activity and the local region, weather, and topography, hiring a guide could be a matter of life and death. In some regions, foreign visitors are required to hire guides.
  6. When you want to hand over the boring logistics. The hassle of obtaining tickets, timing reservations, checking operating hours and figuring out the details is easy stuff for any experienced travel guide and often paying them is simply worth it for the value you get.
  7. When the language barrier is too severe. When you don?t speak the local language and the locals are unlikely to speak yours, hiring a private tour guide can be invaluable.

Finding a good travel guide can be a challenge since many don?t have a website or market themselves. Often, however, asking other tourists or the locals once you get there can garner a good recommendations. Some websites have begun popping up to advertise local guides as well as giving you an idea of their credentials.

What should you look for in a travel guide?

A good tour guide will have been living in the region for some time because they chose to. They may have grown up there and never wanted to leave, or they may be foreigners themselves and found the region you?re visiting and became a local. Either way, there?s a reason they are where they are and doing what they do ? it?s because the love the area, they know the area, and they like sharing it with others.

Just remember while a travel guide is especially helpful when you don?t know the local language, the common language of smiling and knowing a few basic words and phrases will get a traveler pretty darn far too.

Source: http://www.travelinsurancereview.net/2013/04/08/benefits-to-hiring-a-private-travel-guide/?utm_source=rss&utm_medium=rss&utm_campaign=benefits-to-hiring-a-private-travel-guide

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Drew Barrymore: Woman Cannot Have It All

Source: http://www.thehollywoodgossip.com/2013/04/drew-barrymore-woman-cannot-have-it-all/

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Are NKorea's neighbors at risk of nuclear strike?

WASHINGTON (AP) ? North Korea is widely recognized as being years away from perfecting the technology to back up its bold threats of a pre-emptive strike on America. But some nuclear experts say it might have the know-how to fire a nuclear-tipped missile at South Korea and Japan, which host U.S. military bases.

No one can tell with any certainty how much technological progress North Korea has made, aside from perhaps a few people close to its secretive leadership.

If true, it is unlikely the North would launch such an attack because the retaliation would be devastating.

The North's third nuclear test on Feb. 12, which prompted the toughest U.N. Security Council penalties yet, is presumed to have advanced its ability to miniaturize a nuclear device.

Experts say it's easier to design a nuclear warhead that works on a shorter-range missile than one for an intercontinental missile that could target the U.S.

The assessment of David Albright at the Institute for Science and International Security think-tank is that North Korea has the capability to mount a warhead on its Nodong missile, which has a range of 800 miles (1,280 kilometers) and could hit in South Korea and most of Japan.

He said in his analysis, published after the latest nuclear test, that it is an uncertain estimate, and the warhead's reliability remains unclear.

Albright contends that the experience of Pakistan could serve as precedent.

Pakistan bought the Nodong from North Korea after its first flight test in 1993, then adapted and produced it for its own use. Pakistan, which conducted its first nuclear test in 1998, is said to have taken less than 10 years to miniaturize a warhead before that test, Albright said.

North Korea also obtained technology from the trafficking network of A.Q. Khan, a disgraced pioneer of Pakistan's nuclear program, acquiring centrifuges for enriching uranium. According to the Congressional Research Service, Khan may also have supplied a Chinese-origin nuclear weapon design he provided to Libya and Iran, which could have helped the North in developing a warhead for a ballistic missile.

But Siegfried Hecker at Stanford University's Center for International Security and Cooperation, who has visited North Korea seven times and been granted unusual access to its nuclear facilities, is skeptical the North has advanced that far in miniaturization of a nuclear device.

"Nobody outside of a small elite in North Korea knows ? and even they don't know for sure," he said in an emailed response to questions from The Associated Press. "I agree that we cannot rule it out for one of their shorter-range missiles, but we simply don't know."

"Thanks to A.Q. Khan, they almost certainly have designs for such a device that could fit on some of their short- or medium-range missiles," said Hecker, who last visited the North in November 2010. "But it is a long way from having a design and having confidence that you can put a warhead on a missile and have it survive the thermal and mechanical stresses during launch and along its entire trajectory."

The differing opinions underscore a fundamental problem in assessing a country as isolated as North Korea, particularly its weapons programs: solid proof is very hard to come by.

For example, the international community remains largely in the dark about the latest underground nuclear test.

Although it caused a magnitude 5.1 tremor, no gases escaped and experts say there was no way to evaluate whether a plutonium or uranium device was detonated. That information would help reveal whether North Korea has managed to produce highly enriched uranium, giving it a new source of fissile material, and help determine the type and sophistication of the North's warhead design.

The guessing game about the North's nuclear weapons program dates back decades.

Albright says that in the early 1990s, the CIA estimated that North Korea had a "first-generation" design for a plutonium device that was likely to be deployed on the Nodong missile ? although it's not clear what information that estimate was based on.

"Given that 20 years has passed since the deployment of the Nodong, an assessment that North Korea successfully developed a warhead able to be delivered by that missile is reasonable," Albright wrote.

According to Nick Hansen, a retired intelligence expert who closely monitors developments in the North's weapons programs, the Nodong missile was first flight-tested in 1993. Pakistan claims to have re-engineered the missile and successfully tested it, although doubts apparently persist about its reliability.

Whether North Korea has also figured out how to wed the missile with a nuclear warhead has major ramifications not just for South Korea and Japan, but for the U.S. itself, which counts those nations as its principal allies in Asia and retains 80,000 troops in the two countries.

U.S. intelligence appears to have vacillated in its assessments of North Korea's capabilities.

In April 2005, Lowell Jacoby, director of the Defense Intelligence Agency, told the Senate Armed Services Committee that North Korea had the capability to arm a missile with a nuclear device. Pentagon officials, however, later backtracked.

According to the Congressional Research Service, a report from the same intelligence agency to Congress in August 2007 said that "North Korea has short and medium-range missiles that could be fitted with nuclear weapons, but we do not know whether it has in fact done so."

In an interview Friday in Germany, Gen. Martin Dempsey, chairman of the Joint Chiefs of Staff, said the U.S. does not know whether North Korea has "weaponized" its nuclear capability.

Still, Washington is taking North Korea's nuclear threats seriously.

The bellicose rhetoric follows not just the nuclear test in February, but the launch in December of a long-range North Korean rocket that could potentially hit the continental U.S.

According to South Korean officials, North Korea has moved at least one missile with "considerable range" to its east coast ? possibly the untested Musudan missile, believed to have a range of 1,800 miles (3,000 kilometers).

This past week, the U.S. said two of the Navy's missile-defense ships were positioned closer to the Korean peninsula, and a land-based system is being deployed for the Pacific territory of Guam. The Pentagon last month announced longer-term plans to beef up its U.S.-based missile defenses.

South Korea is separated from North Korea and its huge standing army by a heavily militarized frontier, and the countries remain in an official state of war, as the Korean War ended in 1953 without a peace treaty.

Even without nuclear arms, the North positions enough artillery within range of Seoul to devastate large parts of the capital before the much-better-equipped U.S. and South Korea could fully respond.

Japan has been starkly aware of the threat since North Korea's 1998 test of the medium-range Taepodong missile that overflew its territory.

In the latest standoff, much of the international attention has been on the North's potential threat to the U.S., a more distant prospect than its capabilities to strike its own neighbors. Experts say the North could hit South Korea with chemical weapons, and might also be able to use a Scud missile to carry a nuclear warhead.

Darryl Kimball, executive director of the Arms Control Association, acknowledges the North might be able to put a warhead on a Nodong missile, but he sees it as unlikely. He says the North's nuclear threats are less worthy of attention than the prospects of a miscalculation leading to a conventional war.

"North Korea understands that a serious attack on South Korea or other U.S. interests is going to be met with overwhelming force," he said. "It would be near suicidal for the regime."

____

Associated Press writers Foster Klug in Seoul, South Korea, and Robert Burns in Stuttgart, Germany, contributed to this report.

Source: http://news.yahoo.com/nkoreas-neighbors-risk-nuclear-strike-175321030.html

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Developmental delays in children following prolonged seizures

Apr. 4, 2013 ? Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus (CSE) -- a seizure lasting longer than thirty minutes. The study appearing today in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), suggests that neurodevelopmental impairments continue to be present one year after CSE.

CSE is one of the most common neurological emergencies in children. These prolonged seizures can occur with or without fevers (febrile). Studies show that CSE occurs more frequently during the first three years of life -- a time of critical growth and development in children. Prior research investigating CSE has focused mainly on simple febrile seizures and was conducted years after the event occurred.

"Our study is the first to examine cognitive, language, and motor function in children within six weeks of CSE, with follow-up at one year to determine their developmental track," said lead author, Dr. Marina Martinos with the Developmental Cognitive Neurosciences Unit at UCL Institute of Child Health in London. "Understanding how CSE impacts early childhood development and whether this type of seizure has long-term adverse affects is an important addition to medical evidence."

For the present study, researchers recruited 54 children between one and forty-two months of age who had at least one CSE event. CSE episodes were classified as prolonged febrile seizures (PFS) or nonfebrile CSE. All pediatric participants underwent neuropsychological assessments and imaging scans within six weeks of the CSE event and at one year. Developmental skills were measured in children who had seizures and compared to children without seizures with normal development.

Half of the pediatric participants had PFS and the other half had nonfebrile CSE, with assessments carried out at a mean of 38 days following CSE. Findings indicate that CSE is linked to developmental impairments within six weeks of the event, and that the impairments persisted at the one-year follow-up. Children with nonfebrile PFS had worse developmental outcomes than those with PFS, and children in the PFS group had poorer developmental skills than those in the control group. The authors found that seizure characteristics (e.g. duration) were not a significant predictor of developmental performance.

Dr. Martinos concludes, "We found developmental impairments in children following CSE, including those with PFS who normally do not display neurologic issues prior to the seizure. The fact that neurodevelopmental impairments are still present at one year after the episode suggests that the CSE event is not having just a transient effect on developmental abilities. The CSE may have a longer lasting impact on future development through a more permanent reorganization of functional brain networks -- a reorganization that may have already taken place when we first assess these children."

Alternatively, the authors comment, these data suggest that the neurodevelopmental impairments observed predate the seizure even in those with no neurological priors. The authors propose that further studies that include neurocognitive techniques are necessary to enhance understanding of the long-term impact of CSE on child development.

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The above story is reprinted from materials provided by Wiley.

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Journal Reference:

  1. Marina M. Martinos, Michael Yoong, Shekhar Patil, Wui K. Chong, Rodica Mardari, Richard F. M. Chin, Brian G. R. Neville, Michelle de Haan, Rod C. Scott. Early developmental outcomes in children following convulsive status epilepticus: A longitudinal study. Epilepsia, 2013; DOI: 10.1111/epi.12136

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/Rd1pRlP_F2I/130408085048.htm

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