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Wednesday, February 22, 2012
French parliament approves Europe bailout fund (AP)
[unable to retrieve full-text content]AP - The French lower house of parliament has approved financing for the permanent European bailout fund and new belt-tightening measures for France.
Who're the very best E-mail marketing Companies and ways to ...
Posted on by Matheus in Flower Gardening
While i speak with small businesses building the e-mail list on-line I?m frequently asked which can be the highest email marketing companies and ways to choose between them.
There are various organizations online and who is the highest is dependent regarding how you define ?top? I reckon that.
Can it be this company with buyers?
The company with all the greatest deliverability fee?
The company with overall subscribers?
The company who is manufactured as much as possible?
Can it be the program with features?
Essentially we shall should define this lower a bit more prior to a selection which usually organization to build your own list with.
The following is the with the the key features and sole e35 elliptical as well as e-mail supplier ought to supply:
One. Higher Deliverability: This might rather be one of the most crucial features to obtain a top organization. You choose your own e-mail to have sent just about every moment. Regrettably frequently e-mail just aren?t getting over the really rigid junk e-mail filtration systems regarding present day e-mail plans and internet service providers. A message marketing organization which include developed a good relationship with e-mail and internet service providers could possibly be ?whitelisted? to ensure that his or her e-mail are delivered by means of although some are clogged. Be certain this company you select includes a large deliverability fee, since around for you to 100% as you can.
Two. Twice Opt-in: As a way to stick to the particular Can-Spam regulations you have to make certain your own subscribers really opted for acquire your own vertical blinds. This could be done through placing them by using a dual opt-in procedure.
3. Templates: A fantastic e-mail supplier could also provide you with a a lot of good quality web templates to apply with your e-mail. This protects you time and money in having them produced oneself.
Some. Checking: Understanding what works and what won?t would be the center associated with a organization and it?s really the exact same when executing internet business. A fantastic e-mail marketing organization and repair service provider will offer you numerous very good checking options. By way of example, I make the most of Getresponse for my e-mail marketing and they also provide checking so that me to view the amount of subscribers to every one opt-in type I create together with transformation fee. Additionally they do credit reporting round the various sign-ups, keys to press in e-mail, quantity of e-mail opened up plus more.
Five. Autoresponders: One of the best advantages to e-mail marketing would be the chance to create e-mail staying sent immediately. This enables you to build a lots of leverage with your organization to make funds even when you are certainly not operating.
Some. Customer care: Regardless how excellent an enterprise as well as technique is in the event the help is actually horrible it?s all alpine after that. Try out your possible e-mail organizations help by using it. Speak to them, find out and be sure they shall be there to steer you when so when virtually any concerns occur.
Related Blogs
- Related Blogs on email marketing companies
Source: http://organicveggardening.com/whore-the-very-best-e-mail-marketing-companies-and-ways-to-decide-on/
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Tuesday, February 21, 2012
Mardi Gras revelry, parades take over New Orleans
Fleambeaux Carriers march along side the Captain's float in the Mardi Gras parade in New Orleans, Monday, Feb. 20, 2012.(AP Photo/Bill Haber)
Fleambeaux Carriers march along side the Captain's float in the Mardi Gras parade in New Orleans, Monday, Feb. 20, 2012.(AP Photo/Bill Haber)
Riders in the Mardi Gras parade make their way to their float in the staging area of the parade in New Orleans, Monday, Feb. 20, 2012. (AP Photo/Bill Haber)
Entertainer Cyndi Lauper throws beads while riding in the Mardi Gras parade in New Orleans, Monday, Feb. 20, 2012.(AP Photo/Bill Haber)
Entertainer Bret Michaels holds a handful of beads while riding in the Mardi Gras parade in New Orleans, Monday, Feb. 20, 2012. (AP Photo/Bill Haber)
NEW ORLEANS (AP) ? Revelers hit the streets Tuesday to celebrate Mardi Gras, lured to the French Quarter and stately oak-lined avenues by the chance to snag beads and baubles from seemingly endless parades in the final unfettered party before the somber season of Lent.
The French Quarter was full of costumed revelers. Wearing a bright orange wig, a purple mask and green shoes, New Orleans resident Charlotte Hamrick walked along Canal Street to meet friends.
"I'll be in the French Quarter all day," Hamrick said. "I don't even go to the parades. I love to take pictures of all the costumes and just be with my friends. It's so fun."
Brittany Davies of Denver was struggling through the early morning hours. Still feeling the effects of heavy drinking from the night before, her friends had her out again early Tuesday.
"They're torturing me," Davies joked. "But I'll be OK after a bloody Mary."
At the Superdome, the predominantly African-American Zulu krewe loaded their floats with their signature decorated coconuts, a parade crowd favorite. Most were in the traditional black-face makeup and afro wigs krewe members have sported for decades.
Meanwhile in the Garden District, clarinetist Pete Fountain prepared to lead his Half-Fast Walking Club on its annual march down St. Charles Avenue, the traditional start of the daylong series of parades.
After Zulu, the parade of Rex, king of Carnival, would make the trek down the avenue and to the city's business district, with hundreds of thousands of people pleading for beads and doubloons.
Fountain, 82, gave a "thumbs up" to start off and his band launched into "When The Saints Come Marching In" as they rounded the corner onto St. Charles Avenue shortly after 7 a.m. It was the 52nd time that Fountain's group has paraded for Mardi Gras. This year, the group wore bright yellow suits and matching pork pie hats for its theme, "Follow the Yellow Brick Road."
Along St. Charles, groups of people, many in costumes, breakfasted as children played in the street. Small marching groups were already on the move. The Skeleton Krewe, 25 people dressed in black skeleton outfits, were on their way to the St. Louis Cathedral.
Tom White, 46, clad in a pink tu-tu, bicycled down the avenue with his wife, Allison, on their way to the French Quarter. "I'm the pink fairy this year," said White. Allison White was not in costume. "He's disgraced the family enough," she said of her husband.
But Tom White was in the spirit of the day. "Costuming is the real fun of Mardi Gras. I'm not too creative but when you weigh 200 pounds and put on a tu-tu people still take your picture."
The stakeout for prime spots along the Mardi Gras parade route started Monday, with legions of Carnival die-hards jockeying for the best places to vie for beads thrown from floats on Fat Tuesday.
Stephanie Chapman and her family had set up in their usual spot on the St. Charles streetcar tracks. They'd arrive at 4 a.m. on Tuesday and would be staying for the duration. "This is a beautiful day and we'll be here until it's over. It won't rain on my parade, But if it does I won't pay any attention," she said.
Across the Gulf Coast, Mardi Gras was getting into full swing. In the Cajun country of southwest Louisiana, masked riders were preparing to go from town to town, making merry along the way in the Courir du Mardi Gras. And parades were scheduled elsewhere around Louisiana and on the Mississippi and Alabama coasts. The celebration arrived in Louisiana in 1682 when the explorer LaSalle and his party stopped at a place they called Bayou Mardi Gras south of New Orleans to celebrate. The site is now lost to history.
On Monday night, the Lundi Gras celebration culminated with the parade of the Krewe of Orpheus, led by entertainers Harry Connick Jr. and Hilary Swank. Rocker Bret Michaels and Grammy-winning singer Cyndi Lauper ushered in Mardi Gras with musical performances in the wee hours of the morning at the bash that followed the parade.
Revelers in costume danced and posed for pictures with Mardi Gras Indians wearing elaborate costumes with feathers and beads.
The end of Mardi Gras gives way to the beginning of Lent, the period of fasting and repentance before Easter Sunday.
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Traitorous immune cells promote sudden ovarian cancer progression
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Public release date: 20-Feb-2012[ | E-mail |
Share ] Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
First model of aggressive ovarian cancer demonstrates immune system's active role in tumor progression
Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape. The researchers show that it might be possible to restore the immune system by targeting a patient's own dendritic cells.
"Our model shows where the cancer is kept in check for relatively long periods, but once they become noticeable, tumors grow exponentially," said Jos R. Conejo-Garcia, M.D., Ph.D., an associate professor at Wistar and leader of the Tumor Microenvironment and Metastasis Program of Wistar's Cancer Center. "More importantly, we show that by depleting these dendritic cells of the immune system, we can reverse the effect, once again allowing our immune system to recognize the ovarian tumors."
Their findings, presented in the March issue of the Journal of Experimental Medicine, available online now, represent the first successful attempt to model the tumor microenvironment of human ovarian cancer in a mouse model of the disease. In essence, the model replicates the inflammatory surroundings that ovarian tumors experience in humans. The more accurate model provides a better tool for researchers to understand, prevent, and treat tumors.
"Our system uses oncogene-driven tumors that are spontaneously antigenic, thus avoiding the use of artificial foreign antigens that do not accurately replicate what drives anti-tumor immune responses in humans," Conejo-Garcia said.
Ovarian cancer remains one of the most deadly forms of cancer in women. According to the National Cancer Institute, 21,990 women will be diagnosed with ovarian cancer, and 15,460 women will die of the disease this year Because early-stage ovarian cancer does not often exhibit noticeable symptoms, many women are not diagnosed until the cancer is at a later stage, when it is most difficult to treat.
"While we have seen an increase in survival rates for most cancers over the last 40 years, ovarian cancer survival has only improved slightly since the 1970's," Conejo-Garcia said. "We created our ovarian cancer model to get a better understanding of how these tumors acquire such aggressive characteristics and evade the immune system."
According to Conejo-Garcia, their model demonstrates how a localized ovarian tumor flares into an aggressive metastatic disease.
"You can see where, if one ovary is cancerous, it is almost unrecognizable until an instantaneous moment, when it explodes into exponential growth," Conejo-Garcia said. "The key to this moment, our evidence suggests, is in the phenotypic changes taking place in the dendritic cells that are part of the tumor microenvironment."
In healthy tissue, dendritic cells function as sort of alarm system to alert the adaptive part of the immune system to potential threats. They work as antigen-presenting cells, offering foreign or disease-causing molecules (called antigen) to the white blood cells that can then respond to an infection or, in this case, tumorous growths. Amid the ovarian cancer microenvironment, dendritic cells also induce the immune system to attack tumor cells and inhibit their growth.
Until, that is, dendritic cells seem to switch sides.
"We see a change in the dendritic cells themselves, which allows tumors to progress to terminal disease in a very short time," Conejo-Garcia said. "Interestingly, the tumors themselves are still immunogenicthey could still otherwise elicit an immune responseit is just that the dendritic cells are actively suppressing the involvement of other anti-tumor immune cells; primarily T cells."
Conejo-Garcia and his colleagues believe that their findings offer a twist on the emerging theory of "cancer immunoeditting." The immunoeditting hypothesis suggests that the immune system actively "edits" tumor cells to eliminate antigens that are recognized by immune cells, keeping the cancer at bay before it becomes symptomatic. All symptomatic tumors, therefore, represent a failure of the immune system, where tumors lose their immunogenicitytheir ability to trigger and be recognized by our immune system.
The researchers found that that depleting dendritic cells early on accelerating tumor expansion, while removing dendritic cells later on actually delayed the tumor's progression. According to Conejo-Garcia, their findings suggest it is a change in the immune system itself, specifically the dendritic cells, and not primarily any loss of immunogenicity on the part of the tumor.
"It is almost as if anti-tumor T cells become exhausted, they can no longer keep up the effort," Conejo-Garcia said. "Still, our findings suggest that the enduring activity of these T cells would allow us to control metastatic ovarian cancer by targeting the dendritic cells that actively prevent their anti-tumor functions."
In fact, Conejo-Garcia and his colleagues have already developed a strategy to reprogram traitorous dendritic cells. In a an upcoming edition of the journal Cancer Research, available online now, the researchers demonstrate how synthetic RNA molecules can be used to win back the allegiance of dendritic cells and restore their ability to stimulate tumor suppression.
###
Funding for this research was provided through grants from the National Cancer Institute and the Department of Defense.
The lead author of the study is Uciane K. Scarlett, Ph.D., a staff scientist in the Conejo-Garcia laboratory. Wistar co-authors also include Melanie R. Rutkowski, Ph.D. and Ximena Escovar-Fadul. Co-authors from Darmouth Medical School include Adam M. Rauwerdink, Ph.D., Jennifer Fields, Jason Baird, Juan R. Cubillos-Ruiz, Ph.D. (currently at Harvard University), Ana C. Jacobs, Jorge L. Gonzalez, M.D., John Weaver, Ph.D., and Steven Fiering, Ph.D.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 20-Feb-2012[ | E-mail |
Share ] Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
First model of aggressive ovarian cancer demonstrates immune system's active role in tumor progression
Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape. The researchers show that it might be possible to restore the immune system by targeting a patient's own dendritic cells.
"Our model shows where the cancer is kept in check for relatively long periods, but once they become noticeable, tumors grow exponentially," said Jos R. Conejo-Garcia, M.D., Ph.D., an associate professor at Wistar and leader of the Tumor Microenvironment and Metastasis Program of Wistar's Cancer Center. "More importantly, we show that by depleting these dendritic cells of the immune system, we can reverse the effect, once again allowing our immune system to recognize the ovarian tumors."
Their findings, presented in the March issue of the Journal of Experimental Medicine, available online now, represent the first successful attempt to model the tumor microenvironment of human ovarian cancer in a mouse model of the disease. In essence, the model replicates the inflammatory surroundings that ovarian tumors experience in humans. The more accurate model provides a better tool for researchers to understand, prevent, and treat tumors.
"Our system uses oncogene-driven tumors that are spontaneously antigenic, thus avoiding the use of artificial foreign antigens that do not accurately replicate what drives anti-tumor immune responses in humans," Conejo-Garcia said.
Ovarian cancer remains one of the most deadly forms of cancer in women. According to the National Cancer Institute, 21,990 women will be diagnosed with ovarian cancer, and 15,460 women will die of the disease this year Because early-stage ovarian cancer does not often exhibit noticeable symptoms, many women are not diagnosed until the cancer is at a later stage, when it is most difficult to treat.
"While we have seen an increase in survival rates for most cancers over the last 40 years, ovarian cancer survival has only improved slightly since the 1970's," Conejo-Garcia said. "We created our ovarian cancer model to get a better understanding of how these tumors acquire such aggressive characteristics and evade the immune system."
According to Conejo-Garcia, their model demonstrates how a localized ovarian tumor flares into an aggressive metastatic disease.
"You can see where, if one ovary is cancerous, it is almost unrecognizable until an instantaneous moment, when it explodes into exponential growth," Conejo-Garcia said. "The key to this moment, our evidence suggests, is in the phenotypic changes taking place in the dendritic cells that are part of the tumor microenvironment."
In healthy tissue, dendritic cells function as sort of alarm system to alert the adaptive part of the immune system to potential threats. They work as antigen-presenting cells, offering foreign or disease-causing molecules (called antigen) to the white blood cells that can then respond to an infection or, in this case, tumorous growths. Amid the ovarian cancer microenvironment, dendritic cells also induce the immune system to attack tumor cells and inhibit their growth.
Until, that is, dendritic cells seem to switch sides.
"We see a change in the dendritic cells themselves, which allows tumors to progress to terminal disease in a very short time," Conejo-Garcia said. "Interestingly, the tumors themselves are still immunogenicthey could still otherwise elicit an immune responseit is just that the dendritic cells are actively suppressing the involvement of other anti-tumor immune cells; primarily T cells."
Conejo-Garcia and his colleagues believe that their findings offer a twist on the emerging theory of "cancer immunoeditting." The immunoeditting hypothesis suggests that the immune system actively "edits" tumor cells to eliminate antigens that are recognized by immune cells, keeping the cancer at bay before it becomes symptomatic. All symptomatic tumors, therefore, represent a failure of the immune system, where tumors lose their immunogenicitytheir ability to trigger and be recognized by our immune system.
The researchers found that that depleting dendritic cells early on accelerating tumor expansion, while removing dendritic cells later on actually delayed the tumor's progression. According to Conejo-Garcia, their findings suggest it is a change in the immune system itself, specifically the dendritic cells, and not primarily any loss of immunogenicity on the part of the tumor.
"It is almost as if anti-tumor T cells become exhausted, they can no longer keep up the effort," Conejo-Garcia said. "Still, our findings suggest that the enduring activity of these T cells would allow us to control metastatic ovarian cancer by targeting the dendritic cells that actively prevent their anti-tumor functions."
In fact, Conejo-Garcia and his colleagues have already developed a strategy to reprogram traitorous dendritic cells. In a an upcoming edition of the journal Cancer Research, available online now, the researchers demonstrate how synthetic RNA molecules can be used to win back the allegiance of dendritic cells and restore their ability to stimulate tumor suppression.
###
Funding for this research was provided through grants from the National Cancer Institute and the Department of Defense.
The lead author of the study is Uciane K. Scarlett, Ph.D., a staff scientist in the Conejo-Garcia laboratory. Wistar co-authors also include Melanie R. Rutkowski, Ph.D. and Ximena Escovar-Fadul. Co-authors from Darmouth Medical School include Adam M. Rauwerdink, Ph.D., Jennifer Fields, Jason Baird, Juan R. Cubillos-Ruiz, Ph.D. (currently at Harvard University), Ana C. Jacobs, Jorge L. Gonzalez, M.D., John Weaver, Ph.D., and Steven Fiering, Ph.D.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-02/twi-tic021612.php
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Monday, February 20, 2012
Guidelines for ecommerce websites
Published by witter
Ecommerce has become a rich industry, as many consumers are moving online, as the online media channels have increased our dependency over internet. Ecommerce continues to grow up the sales from time to time. Internet has provided an opportunity to the standard shift to promote their brand through internet as it is mainly dependant on the fashion. The offline retailers have moved upon to online close sales as they do not want their existing customers to be lost and however their dependence on direct media channels should not get underrated also. Exploiting the ecommerce means exploiting the search engine algorithms to increase the organic sales, as through this channel and through paid search the advertisers do not look merely for the traffic for branded search results. The ability to derive sales through common as well as brand faltering search queries have created an opportunity to easily scale up and a few barriers to trade as compared to the offline world.
Savvy marketers understand the internet and how to utilize the opportunities it provides. There are number of ecommerce websites designed for them only. The companies offering this website design knows that through this they can easily promote the company, its products and services all over the world through internet.
The very important element of a successful ecommerce web design is to test out new marketing medium which do not require so much of investments. All that it needs to control the functioning of a website is to manage the product browsing, payments, managing your catalog, shipping, order management and SEO marketing facilities. There are many best online store solutions for the ecommerce dealers and is made available to you at very cheap and affordable prices.
To stand different from the thousands of the ecommerce website users, you need to modify your themes and design a unique background experience for the web users.
Come to us at Vibe graphics and get your website design needs solved in the most consistent manner with great Web Design layout. We at Vibe graphics incorporate dazzling website titles in our websites.
Source: http://www.1directory.net/internet-and-businesses-online/guidelines-for-ecommerce-websites-6504.html
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Selecting The Best Real Estate Attorney ? Elisa Massoth ? Example ...
A genuine estate attorney can be a legal professional who handles matters concerning obtaining, selling and every other legal processes throughout property management. This professional will involve himself in encouraging clients in lawful representation in home transfer and disputes as a result of property ownership. Their clientele normally include landlords, tenants, contractors, property developers, institutions that present finance for property developments like banks and another entity that needs his services as well as afford them. Generally, there are two types of real estate law firms, litigators and transactional lawyers. While litigators manage lawsuits, the transactional legal professionals handle matters regarding contracts. However, there are several who can deal with both types.
Elisa Massoth
Your friends might not exactly have a satisfactory step to your queries or there can be absolutely no an individual that has the thought of what you are speaking about. The next remain in a quest for any good professional with this field is any local estate brokers. It is a higher chance that these types of brokers have specialists that handle their own matters. Engage the agencies with questions regarding their real estate investment attorneys and that of this preference. The brokers will probably most certainly provide you with a recommendation or many of them that you can pick the very best. Basically, the recommendation needs to be based on his or her competence and expertise.
Choosing a real estate investment lawyer in its an excellent heavy task but choosing a skilled real estate attorney can be quite stressful job. You may provide an attorney but their not mandatory for them to have knowledge in property law. However you can talk with him as the individual might have excellent sources. Also an online search will let you find the real estate investment attorney office.
Elisa G. Massoth
Another good supply of finding a property lawyer would be the Internet. Go online and look for lawyers in your current locality. Include the name of your respective locality in the actual keyword for specific result. When you will buy or sell real estate you should keep every one of the options open. The more references you will get the healthier.
Once you get a number of references you can easily call the lawyers and have absolutely a little discussion within the telephone. This telephonic interview will let you shortlist some of these. Now that you could have short listed a couple of lawyers meet them in person and ask queries. But make sure you never disclose all your details inside the first meeting. The first meeting is critical just to make certain you are deciding on the best person to combat your case.
For more details please visit http://kmrs.net
? N Example ArticlesAuthor: sarahwilson
This author has published 317 articles so far. More info about the author is coming soon.Additional Articles From ?Online Education?
Source: http://examplearticles.info/selecting-the-best-real-estate-attorney-elisa-massoth.html
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Sunday, February 19, 2012
Engagement Invitation Wordings
Not so long ago once the institute of marriage were built with a larger influence over individuals lives, engagements were very formal, an initial occasion to propose a prolonged relationship to a different person. When living together with no carol sacrament wasn?t a good option, and nor would be a quick divorce if things did not exercise because they planned, an engagement would be a huge step a couple of, or frequently, only for a couple who have been selected to reside together by their own families. Even nowadays, when meeting the best individual is getting progressively difficult, some cultures would rather introduce youthful people who wish to got married and begin a household and appear to talk about some common interests that might be enough to allow them to like one another.
In these instances an engagement party is nearly as vital a meeting because the wedding itself, truly much more compact, and just the close buddies and relatives become asked. Just in case of solemnity, this very day can pretty easily match up against the marriage, therefore it is not unusual to transmit out written invites. The engagement invitation wordings possess a certain protocol to follow along with, that is nice to help keep. You will find compulsory things that need to show up on the invitation card: what they are called from the wedding couple to become, what they are called of the parents or parents when they decide to involve them too. It may start such as this: ?Mr. and Mrs. Johnson along with Mr. and Mrs. Taylor kindly invite you to definitely the engagement ceremony of the boy Jack and daughter Lilly?. Following this it will certainly come the address from the venue, which may be one of the parents? own house, an expensive restaurant or an area terrace, park or garden which may be reserved ahead of time while offering catering. It will also show up on the invitation: the time and date from the event, which may be an evening meal or perhaps a Saturday, Sunday lunch, whichever the household and also the newly-weds prefer.
The not compulsory part is one of the text from the invitation, which could consist following the previous, with a small poetic fragment mentioning towards the atmosphere from the ceremony.The engagement invitation?s not mandatory part can include an estimate about love and happiness, the couple?s favorite author on marriage or engagement, an intimate poem which increases the solemnity from the event. The look may also be very variate, you will find customary figures which could show up on an engagement card: hearts, doves, flowers, different shapes and sizes. Its color may also vary with respect to the taste and budget from the wedding couple to become. But don?t forget, regardless of how perfect the engagement invitation card is, or perhaps is not, it?s only an element of the event, and never even the most crucial one.
Source: http://relationships-engagements.chailit.com/engagement-invitation-wordings.html
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